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[2019 추계국제학술대회] 2019 Ohdang Award Lecture
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대한약학회
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http://www.psk1946.or.kr
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2019-08-08
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602

2019 Ohdang Award Lecture

 

Oct. 15th (Tue), 09:40-10:20, Conference Hall

Title: New challenges for tumor drug resistance

Speaker: Hongyang Wang (National Center for Liver Cancer, China)

    

Research field

Molecular mechanisms of liver cancer carcinogenesis; prevention and early diagnosis of liver cancer; individualized treatment of HCC

    

Education

1973-1977:  Clinical Medicine, Secondary Military Medical University (SMMU), Shanghai, China

1981-1984:  Master of Immunology, SMMU, Shanghai, China

1989-1992:  Doctor of Clinical Biochemistry, University of Ulm, Germany

1992-1995:  Post Doctoral Fellow of Molecular Biology, Max-Planck Institute of Biochemistry, Martinsried bei Munchen, Germany

    

Representative Careers

Development of Glypican-3 diagnostic kit to diagnose hepatocellular carcinoma (HCC), especially for alpha fetoprotein (AFP)-negative patients. The Kit was approved by China Food and Drug Administration (CFDA) in 2014. Dr. Wang also devoted herself in exploring the molecular mechanism and signaling pathway of hepatocarcinogenesis.

    

Specialty & Present Interest

Molecular mechanisms and signaling pathways involved in liver cancer carcinogenesis; prevention and early diagnosis of hepatocellular carcinoma; individualized treatment of HCC

    

Representative papers (2016-2018)

1. Xiang DM, Sun W, Ning BF, Zhou TF, Li XF, Cheng Z, Deng X, Cui XL, Li SC, Xie WF, Wang HY* & Ding J*. The HLF/IL-6/STAT3 Feedforward Circuit Drives Hepatic Stellate Cell Activation to Promote Liver Fibrosis. Gut. 2018;67(9):1704-1715. (IF=17.1)

2. Ou-Yang Q, Lin XM, Zhu YJ, Zheng B, Li L, Yang YC, Hou GJ, Chen X, Luo GJ, Huo F, Leng QB, Gonzalez FJ, Jiang XQ*, Wang HY* & Chen L*. Distinct Role of Nuclear Receptor Corepressor 1 Regulated de novo Fatty Acids Synthesis in Liver Regeneration and Hepatocarcinogenesis. Hepatology. 2018;67(3):1071-1087. (IF=14.08)

3. Cheng Z, He ZY, CaiYC, Zhang C, Fu GB, Liu CC, Li H, Cui XL, Sun W, Xiang DM, Zhou TF, Li SC, Wang HY* & Ding J*. Conversion of hepatoma cells to hepatocyte-like cells by defined hepatocyte nuclear factors. Cell Res. 2018 Dec 18; in press. (IF=15.4)

4. Fu GB, Huang WJ, Zeng M, Zhou X, Wu HP, Liu CC, Wu H, Weng J, Zhang HD, Cai YC, Ashton C, Ding M, Tang D, Zhang BH, Gao Y, Yu WF, Zhai B, He ZY, Wang HY* & Yan HX*. Expansion and differentiation of human hepatocyte-derived liver progenitor-like cells and their use for the study of hepatotropic pathogens. Cell Res. 2019;29(1):8-22. (IF=15.4)

5. Liu J, Jiang J, Mo J, Liu D, Cao D, Wang H, He YF* & Wang HY*.Global DNA 5-Hydroxymethylcytosine and 5-Formylcytosine Contents Are Decreased in the Early Stage of Hepatocellular Carcinoma. Hepatology. 2019;69(1):196-208. (IF=14.08)

6. Fang T, Lv H, Lv G, Li T, Wang C, Han Q, Yu L, Su B, Guo L, Huang S, Cao D, Tang L, Tang S, Wu M, Yang W* & Wang H*. Tumor-derived exosomal miR-1247-3p induces cancer-associated fibroblast activation to foster lung metastasis of liver cancer. Nat Commun. 2018;9(1):191. (IF=12.35)

7. Wang B, Fu J, Yu T, Xu A, Qin W, Yang Z, Chen Y* & Wang HY*. Contradictory effects of mitochondria-and non-mitochondria-targeted antioxidants on hepatocarcinogenesis by altering DNA repair in mice. Hepatology. 2018;67(2):623-635. (IF=14.08)

8. Wu H, Zhou X, Fu GB, He ZY, Wu HP, You P, Ashton C, Wang X, Wang HY* & Yan HX*. Reversible transition between hepatocytes and liver progenitors for in vitro hepatocyte expansion. Cell Res. 2017;27(5):709-712. (IF=15.4)

9. Ke S, Chen S, Dong Z, Hong CS, Zhang Q, Tang L, Yang P, Zhai J, Yan H, Shen F, Zhuang Z, Wen W* & Wang HY*. Erythrocytosis in hepatocellular carcinoma portends poor prognosis by respiratory dysfunction secondary to mitochondrial DNA mutations. Hepatology. 2017;65(1):134-151. (IF=14.08)

10. Xiang D, Cheng Z, Liu H, Wang X, Han T, Sun W, Li X, Yang W, Chen C, Xia M, Liu N, Yin S, Jin G, Lee T, Dong L, Hu H, Wang H* & Ding J*.Shp2 promotes liver cancer stem cell expansion by augmenting β-catenin signaling and predicts chemotherapeutic response of patients. Hepatology. 2017;65(5):1566-1580. (IF=14.08)

11. Hou G, Chen L, Liu G, Li L, Yang Y, Yan HX, Zhang HL, Tang J, Yang YC, Lin X, Chen X, Luo GJ, Zhu Y, Tang S, Zhang J, Liu H, Gu Q, Zhao LH, Li Y, Liu L, Zhou WP* & Wang H*. Aldehyde Dehydrogenase-2 (ALDH2) Opposes HCC Progression By Regulating AMPK Signaling. Hepatology. 2017;65(5):1628-1644. (IF=14.08)

12. Qu L, Ding J, Chen C, Wu ZJ, Liu B, Gao Y, Chen W, Liu F, Sun W, Li XF, Wang X, Wang Y, Xu ZY, Gao L, Yang Q, Xu B, Li YM, Fang ZY, Xu ZP, Bao Y, Wu DS, Miao X, Sun HY, Sun YH, Wang HY* & Wang LH*. Exosome-Transmitted lncARSR Promotes Sunitinib Resistance in Renal Cancer by Acting as a Competing Endogenous RNA. Cancer Cell. 2016;29(5):653-68. (IF= 22.84)

13. Wu FQ, Fang T, Yu LX, Lv GS, Lv HW, Liang D, Li T, Wang CZ, Tan YX, Ding J, Chen Y, Tang L, Guo LN, Tang SH, Yang W* & Wang HY*, ADRB2 signaling promotes HCC progression and sorafenib resistance by inhibiting autophagic degradation of HIF1α. J Hepatol. 2016;65(2):314-24. (IF= 14.91)

14. Wang X, Sun W, Shen W, Xia M, Chen C, Xiang D, Ning B, Cui X, Li H, Li X, Ding J* & Wang H*. Long Non-coding RNA DILC Represses Self-renewal of Liver Cancer Stem Cells via Inhibiting Autocrine IL-6/STAT3 Axis. J Hepatol. 2016;64(6):1283-94. (IF= 14.91)

15. Wang MD, Wu H, Fu GB, Zhang HL, Zhou X, Tang L, Dong LW, Qin CJ, Huang S, Zhao LH, Zeng M, Wu MC, Yan HX* & Wang HY*. Acetyl-CoA carboxylase a promotion of glucose-mediated fatty acid synthesis enhances survival of HCC in mice and patients. Hepatology. 2016;63(4):1272-86. (IF=14.08)

16. Yang Y, Lin X, Lu X, Luo G, Zeng T, Tang J, Jiang F, Li L, Cui X, Huang W, Hou G, Chen X, Ouyang Q, Tang S, Sun H, Chen L, Gonzalez FJ, Wu M, Cong W, Chen L* & Wang HY*. Interferon-microRNA signalling drives liver precancerous lesion formation and hepatocarcinogenesis. Gut. 2016;65(7):1186-201. (IF=17.1)

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